How It Works
Tirzepatide is a dual-action peptide that activates both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors. This dual mechanism enhances insulin sensitivity, reduces appetite, and promotes fat oxidation more effectively than single-receptor agonists. The GIP pathway adds complementary metabolic benefits.
Key Research Findings
- FDA-approved for type 2 diabetes (Mounjaro) and weight management (Zepbound)
- SURMOUNT trials showed up to 22.5% body weight reduction
- Superior glycemic control compared to single GLP-1 agonists in head-to-head trials
- Research exploring benefits for NASH, sleep apnea, and cardiovascular outcomes
Common Research Protocols
Use our free dosing calculator to determine exact syringe units after reconstitution.
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Follow these steps to properly reconstitute GLP-2 (Tirzepatide) for research use:
- Step 1: Swab the tops of both the peptide vial and bacteriostatic water vial with alcohol.
- Step 2: Draw your desired amount of BAC water (commonly 1–2 mL) into an insulin syringe.
- Step 3: Inject the water slowly into the peptide vial, aiming at the glass wall — not directly onto the powder.
- Step 4: Swirl the vial gently until fully dissolved — never shake.
- Step 5: Refrigerate at 36–46°F (2–8°C). Use within 4–6 weeks.
Use the dosing calculator to calculate your exact concentration (mcg per unit) and how many units to draw on your syringe.
Frequently Asked Questions
- FDA-approved for type 2 diabetes (Mounjaro) and weight management (Zepbound)
- SURMOUNT trials showed up to 22.5% body weight reduction
- Superior glycemic control compared to single GLP-1 agonists in head-to-head trials
- Research exploring benefits for NASH, sleep apnea, and cardiovascular outcomes
Need to Calculate Your GLP-2 (Tirzepatide) Dose?
Use our free reconstitution calculator for precise syringe measurements.
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