Cagrilintide

How It Works

Cagrilintide mimics amylin, a hormone co-secreted with insulin from pancreatic beta cells. It activates amylin receptors in the brain to reduce appetite, slow gastric emptying, and suppress glucagon secretion. Its long half-life (approximately 7 days) enables once-weekly dosing. When combined with semaglutide (as in CagriSema), the dual-agonist approach targets multiple satiety pathways simultaneously.

Key Research Findings

• CagriSema (cagrilintide + semaglutide) achieved up to 25% body weight reduction in trials
• Superior weight loss compared to semaglutide alone in head-to-head studies
• Significant improvements in glycemic control and metabolic markers
• Currently in Phase III clinical trials for obesity and type 2 diabetes

Common Research Protocols

Use our free dosing calculator to determine exact syringe units after reconstitution.

Reconstitution Guide

Follow these steps to properly reconstitute Cagrilintide for research use:

• Step 1: Swab the tops of both the peptide vial and bacteriostatic water vial with alcohol.
• Step 2: Draw your desired amount of BAC water (commonly 1–2 mL) into an insulin syringe.
• Step 3: Inject the water slowly into the peptide vial, aiming at the glass wall — not directly onto the powder.
• Step 4: Swirl the vial gently until fully dissolved — never shake.
• Step 5: Refrigerate at 36–46°F (2–8°C). Use within 4–6 weeks.

Use the dosing calculator to calculate your exact concentration (mcg per unit) and how many units to draw on your syringe.

Frequently Asked Questions

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