How It Works
Semaglutide binds to GLP-1 receptors, enhancing glucose-dependent insulin secretion, suppressing glucagon release, slowing gastric emptying, and reducing appetite through central nervous system pathways. Its long half-life allows for once-weekly dosing.
Key Research Findings
- FDA-approved for type 2 diabetes (Ozempic) and weight management (Wegovy)
- Clinical trials show average 15–17% body weight reduction
- Significant improvements in glycemic control and cardiovascular markers
- Research exploring neuroprotective and anti-inflammatory properties
Common Research Protocols
Research Dosing Range
Dosing follows a slow titration: start at 0.25 mg once weekly for 4 weeks, increase to 0.5 mg for 4 weeks, then titrate up monthly in 0.5 mg increments to a maintenance dose of 1–2.4 mg weekly. Slow titration is critical to minimize GI side effects.
Use our free dosing calculator to determine exact syringe units after reconstitution.
Sponsored
Premium third-party tested, research-grade peptides including GLP-1 (Semaglutide). Explore 40+ products.
Shop Valor Sciences →Reconstitution Guide
Follow these steps to properly reconstitute GLP-1 (Semaglutide) for research use:
- Step 1: Swab the tops of both the peptide vial and bacteriostatic water vial with alcohol.
- Step 2: Draw your desired amount of BAC water (commonly 1–2 mL) into an insulin syringe.
- Step 3: Inject the water slowly into the peptide vial, aiming at the glass wall — not directly onto the powder.
- Step 4: Swirl the vial gently until fully dissolved — never shake.
- Step 5: Refrigerate at 36–46°F (2–8°C). Use within 4–6 weeks.
Use the dosing calculator to calculate your exact concentration (mcg per unit) and how many units to draw on your syringe.
Frequently Asked Questions
How does GLP-1 (Semaglutide) work? ▾
Semaglutide binds to GLP-1 receptors, enhancing glucose-dependent insulin secretion, suppressing glucagon release, slowing gastric emptying, and reducing appetite through central nervous system pathways. Its long half-life allows for once-weekly dosing.
What are the key research findings? ▾
- FDA-approved for type 2 diabetes (Ozempic) and weight management (Wegovy)
- Clinical trials show average 15–17% body weight reduction
- Significant improvements in glycemic control and cardiovascular markers
- Research exploring neuroprotective and anti-inflammatory properties
What is the typical dosing protocol? ▾
Dosing follows a slow titration: start at 0.25 mg once weekly for 4 weeks, increase to 0.5 mg for 4 weeks, then titrate up monthly in 0.5 mg increments to a maintenance dose of 1–2.4 mg weekly. Slow titration is critical to minimize GI side effects.
How should GLP-1 (Semaglutide) be stored? ▾
Unreconstituted powder should be stored in a freezer or refrigerator away from light and moisture. Once reconstituted with bacteriostatic water, refrigerate at 36–46°F (2–8°C) and use within 4–6 weeks. Never freeze reconstituted peptides.
Need to Calculate Your GLP-1 (Semaglutide) Dose?
Use our free reconstitution calculator for precise syringe measurements.
Open Dosing Calculator →