How It Works
Thymosin Beta-4 sequesters G-actin (monomeric actin), regulating actin polymerization which is essential for cell migration, proliferation, and differentiation. It promotes angiogenesis, reduces inflammation through NF-κB modulation, and activates cardiac progenitor cells. TB-500 is a synthetic fragment of Thymosin Beta-4 containing the active region, but full-length Tβ4 provides additional biological activities.
Reconstitution Guide
Follow these steps to properly reconstitute Thymosin Beta-4 for research use:
- Step 1: Swab the tops of both the peptide vial and bacteriostatic water vial with alcohol.
- Step 2: Draw your desired amount of BAC water (commonly 1–2 mL) into an insulin syringe.
- Step 3: Inject the water slowly into the peptide vial, aiming at the glass wall — not directly onto the powder.
- Step 4: Swirl the vial gently until fully dissolved — never shake.
- Step 5: Refrigerate at 36–46°F (2–8°C). Use within 4–6 weeks.
Use the dosing calculator to calculate your exact concentration (mcg per unit) and how many units to draw on your syringe.
Frequently Asked Questions
How does Thymosin Beta-4 work? ▾
Thymosin Beta-4 sequesters G-actin (monomeric actin), regulating actin polymerization which is essential for cell migration, proliferation, and differentiation. It promotes angiogenesis, reduces inflammation through NF-κB modulation, and activates cardiac progenitor cells. TB-500 is a synthetic fragment of Thymosin Beta-4 containing the active region, but full-length Tβ4 provides additional biological activities.
What are the key research findings? ▾
- Promotes tissue repair across muscle, tendons, ligaments, skin, and cardiac tissue
- Cardioprotective properties — activates cardiac progenitor cells after ischemia
- Reduces fibrosis and scar formation in multiple tissue types
- Currently in clinical trials for wound healing and cardiac repair applications
What is the typical dosing protocol? ▾
Loading phase: 2–5 mg subcutaneously twice weekly for 4–6 weeks. Maintenance: 2–5 mg once every 1–2 weeks. Often used interchangeably with TB-500 (its active fragment). Commonly stacked with BPC-157 for comprehensive healing protocols.
How should Thymosin Beta-4 be stored? ▾
Unreconstituted powder should be stored in a freezer or refrigerator away from light and moisture. Once reconstituted with bacteriostatic water, refrigerate at 36–46°F (2–8°C) and use within 4–6 weeks. Never freeze reconstituted peptides.