How It Works
KPV (Lys-Pro-Val) retains the anti-inflammatory signaling of its parent molecule α-MSH but without binding to melanocortin receptors. It reduces inflammation by inhibiting NF-κB activation, decreasing pro-inflammatory cytokines (TNF-α, IL-6, IL-1β), and penetrating cell membranes to exert intracellular anti-inflammatory effects. It is particularly studied for gastrointestinal inflammation.
Reconstitution Guide
Follow these steps to properly reconstitute KPV for research use:
- Step 1: Swab the tops of both the peptide vial and bacteriostatic water vial with alcohol.
- Step 2: Draw your desired amount of BAC water (commonly 1–2 mL) into an insulin syringe.
- Step 3: Inject the water slowly into the peptide vial, aiming at the glass wall — not directly onto the powder.
- Step 4: Swirl the vial gently until fully dissolved — never shake.
- Step 5: Refrigerate at 36–46°F (2–8°C). Use within 4–6 weeks.
Use the dosing calculator to calculate your exact concentration (mcg per unit) and how many units to draw on your syringe.
Frequently Asked Questions
How does KPV work? ▾
KPV (Lys-Pro-Val) retains the anti-inflammatory signaling of its parent molecule α-MSH but without binding to melanocortin receptors. It reduces inflammation by inhibiting NF-κB activation, decreasing pro-inflammatory cytokines (TNF-α, IL-6, IL-1β), and penetrating cell membranes to exert intracellular anti-inflammatory effects. It is particularly studied for gastrointestinal inflammation.
What are the key research findings? ▾
- Potent reduction of intestinal inflammation in IBD animal models
- Directly inhibits NF-κB signaling — a master switch of inflammation
- Does not cause skin darkening or hormonal effects (unlike melanotan)
- Shown to accelerate wound healing and reduce inflammatory skin conditions
What is the typical dosing protocol? ▾
Subcutaneous injection: 200–500 mcg 1–2 times daily. Oral/capsule forms are also studied for direct GI effects. Some researchers use BPC-157 + KPV stacks for comprehensive gut healing protocols. Cycles typically run 4–8 weeks.
How should KPV be stored? ▾
Unreconstituted powder should be stored in a freezer or refrigerator away from light and moisture. Once reconstituted with bacteriostatic water, refrigerate at 36–46°F (2–8°C) and use within 4–6 weeks. Never freeze reconstituted peptides.