KPV

How It Works

KPV (Lys-Pro-Val) retains the anti-inflammatory signaling of its parent molecule α-MSH but without binding to melanocortin receptors. It reduces inflammation by inhibiting NF-κB activation, decreasing pro-inflammatory cytokines (TNF-α, IL-6, IL-1β), and penetrating cell membranes to exert intracellular anti-inflammatory effects. It is particularly studied for gastrointestinal inflammation.

Key Research Findings

• Potent reduction of intestinal inflammation in IBD animal models
• Directly inhibits NF-κB signaling — a master switch of inflammation
• Does not cause skin darkening or hormonal effects (unlike melanotan)
• Shown to accelerate wound healing and reduce inflammatory skin conditions

Common Research Protocols

Use our free dosing calculator to determine exact syringe units after reconstitution.

Reconstitution Guide

Follow these steps to properly reconstitute KPV for research use:

• Step 1: Swab the tops of both the peptide vial and bacteriostatic water vial with alcohol.
• Step 2: Draw your desired amount of BAC water (commonly 1–2 mL) into an insulin syringe.
• Step 3: Inject the water slowly into the peptide vial, aiming at the glass wall — not directly onto the powder.
• Step 4: Swirl the vial gently until fully dissolved — never shake.
• Step 5: Refrigerate at 36–46°F (2–8°C). Use within 4–6 weeks.

Use the dosing calculator to calculate your exact concentration (mcg per unit) and how many units to draw on your syringe.

Frequently Asked Questions

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