How It Works
Hexarelin binds to both the ghrelin receptor (GHS-R1a) and the CD36 receptor. The GHS-R1a binding triggers potent GH release, while CD36 binding mediates cardioprotective effects including improved cardiac contractility and coronary artery dilation. Unlike other GHRPs, it does not significantly increase appetite due to its limited effect on ghrelin.
Reconstitution Guide
Follow these steps to properly reconstitute Hexarelin for research use:
- Step 1: Swab the tops of both the peptide vial and bacteriostatic water vial with alcohol.
- Step 2: Draw your desired amount of BAC water (commonly 1–2 mL) into an insulin syringe.
- Step 3: Inject the water slowly into the peptide vial, aiming at the glass wall — not directly onto the powder.
- Step 4: Swirl the vial gently until fully dissolved — never shake.
- Step 5: Refrigerate at 36–46°F (2–8°C). Use within 4–6 weeks.
Use the dosing calculator to calculate your exact concentration (mcg per unit) and how many units to draw on your syringe.
Frequently Asked Questions
How does Hexarelin work? ▾
Hexarelin binds to both the ghrelin receptor (GHS-R1a) and the CD36 receptor. The GHS-R1a binding triggers potent GH release, while CD36 binding mediates cardioprotective effects including improved cardiac contractility and coronary artery dilation. Unlike other GHRPs, it does not significantly increase appetite due to its limited effect on ghrelin.
What are the key research findings? ▾
- Produces the highest GH release of all GHRP peptides
- Significant cardioprotective properties via CD36 receptor pathway
- Minimal appetite stimulation compared to GHRP-6
- May desensitize with prolonged use — cyclical dosing recommended
What is the typical dosing protocol? ▾
100–200 mcg subcutaneously 1–2 times daily. Due to desensitization concerns, cycles are typically shorter (4–8 weeks) with equal time off between cycles. Often used as an alternative to Ipamorelin when maximum GH release is the research goal.
How should Hexarelin be stored? ▾
Unreconstituted powder should be stored in a freezer or refrigerator away from light and moisture. Once reconstituted with bacteriostatic water, refrigerate at 36–46°F (2–8°C) and use within 4–6 weeks. Never freeze reconstituted peptides.