Tesofensine

How It Works

Tesofensine inhibits the reuptake of three key neurotransmitters: serotonin, norepinephrine, and dopamine. This triple-action mechanism suppresses appetite through serotonergic pathways, increases thermogenesis and energy expenditure through noradrenergic pathways, and enhances motivation and reward through dopaminergic pathways. The combined effect produces significant and sustained weight loss.

Key Research Findings

• Phase II trials showed 10.6% body weight reduction at 0.5 mg — twice that of existing drugs at the time
• Significant appetite suppression and increased thermogenesis
• May improve mood and cognitive function through dopamine enhancement
• Potential cardiovascular concerns (elevated heart rate and blood pressure) require monitoring

Common Research Protocols

Use our free dosing calculator to determine exact syringe units after reconstitution.

Reconstitution Guide

Follow these steps to properly reconstitute Tesofensine for research use:

• Step 1: Swab the tops of both the peptide vial and bacteriostatic water vial with alcohol.
• Step 2: Draw your desired amount of BAC water (commonly 1–2 mL) into an insulin syringe.
• Step 3: Inject the water slowly into the peptide vial, aiming at the glass wall — not directly onto the powder.
• Step 4: Swirl the vial gently until fully dissolved — never shake.
• Step 5: Refrigerate at 36–46°F (2–8°C). Use within 4–6 weeks.

Use the dosing calculator to calculate your exact concentration (mcg per unit) and how many units to draw on your syringe.

Frequently Asked Questions

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