How It Works
SS-31 selectively targets cardiolipin in the inner mitochondrial membrane due to its alternating aromatic-cationic motif. By stabilizing cardiolipin-cytochrome c interactions, it optimizes electron transport chain efficiency, reduces reactive oxygen species (ROS) production, and prevents mitochondrial-triggered apoptosis. This restores energy production at the cellular level.
Reconstitution Guide
Follow these steps to properly reconstitute SS-31 (Elamipretide) for research use:
- Step 1: Swab the tops of both the peptide vial and bacteriostatic water vial with alcohol.
- Step 2: Draw your desired amount of BAC water (commonly 1–2 mL) into an insulin syringe.
- Step 3: Inject the water slowly into the peptide vial, aiming at the glass wall — not directly onto the powder.
- Step 4: Swirl the vial gently until fully dissolved — never shake.
- Step 5: Refrigerate at 36–46°F (2–8°C). Use within 4–6 weeks.
Use the dosing calculator to calculate your exact concentration (mcg per unit) and how many units to draw on your syringe.
Frequently Asked Questions
How does SS-31 (Elamipretide) work? ▾
SS-31 selectively targets cardiolipin in the inner mitochondrial membrane due to its alternating aromatic-cationic motif. By stabilizing cardiolipin-cytochrome c interactions, it optimizes electron transport chain efficiency, reduces reactive oxygen species (ROS) production, and prevents mitochondrial-triggered apoptosis. This restores energy production at the cellular level.
What are the key research findings? ▾
- Concentrates 5,000-fold in mitochondria compared to cytoplasm
- Restores mitochondrial function in aging cells and tissues
- In clinical trials for heart failure, Barth syndrome, and age-related macular degeneration
- Reversed age-related vascular stiffness and improved cardiac function in animal models
What is the typical dosing protocol? ▾
Subcutaneous injection: 0.5–5 mg once daily. Clinical trials have used doses up to 40 mg IV. Cycles in research typically run 4–8 weeks. This is a compound with active clinical trials — check ClinicalTrials.gov for the latest data on dosing and outcomes.
How should SS-31 (Elamipretide) be stored? ▾
Unreconstituted powder should be stored in a freezer or refrigerator away from light and moisture. Once reconstituted with bacteriostatic water, refrigerate at 36–46°F (2–8°C) and use within 4–6 weeks. Never freeze reconstituted peptides.