Humanin

How It Works

Humanin is a 24-amino acid peptide encoded within the mitochondrial genome. It protects cells from apoptosis by interacting with BAX (a pro-apoptotic protein), activating STAT3 signaling, and binding to IGFBP-3. It reduces oxidative stress, improves mitochondrial function, and modulates insulin sensitivity. Its levels naturally decline with age.

Key Research Findings

• Discovered in surviving neurons of Alzheimer's patients — suggests neuroprotective role
• Protects against amyloid-beta toxicity, a hallmark of Alzheimer's disease
• Improves insulin sensitivity and metabolic function in animal models
• Circulating humanin levels decline with age and correlate with longevity markers

Common Research Protocols

Use our free dosing calculator to determine exact syringe units after reconstitution.

Reconstitution Guide

Follow these steps to properly reconstitute Humanin for research use:

• Step 1: Swab the tops of both the peptide vial and bacteriostatic water vial with alcohol.
• Step 2: Draw your desired amount of BAC water (commonly 1–2 mL) into an insulin syringe.
• Step 3: Inject the water slowly into the peptide vial, aiming at the glass wall — not directly onto the powder.
• Step 4: Swirl the vial gently until fully dissolved — never shake.
• Step 5: Refrigerate at 36–46°F (2–8°C). Use within 4–6 weeks.

Use the dosing calculator to calculate your exact concentration (mcg per unit) and how many units to draw on your syringe.

Frequently Asked Questions

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