How It Works
Semax is a heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) that enhances BDNF and NGF expression, stimulates dopaminergic and serotonergic systems, and has melanocortin receptor activity. Despite being derived from ACTH, it does not stimulate adrenal cortex hormone production, making it safe for cognitive research.
Key Research Findings
- Increases BDNF expression by up to 800% in certain brain regions
- Research shows improved attention, memory consolidation, and learning
- Studied for stroke recovery and neuroprotective applications in Russia
- May enhance immune function through immunomodulatory pathways
Common Research Protocols
Research Dosing Range
Intranasal administration at 200–600 mcg 1–2 times daily. Beginners start at 200 mcg once daily in the morning. Subcutaneous injection at similar doses is also studied. Cycles commonly run 10–20 days with equal time off between. Often stacked with Selank for combined anxiolytic and cognitive effects.
Use our free dosing calculator to determine exact syringe units after reconstitution.
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Shop Valor Sciences →Reconstitution Guide
Follow these steps to properly reconstitute Semax for research use:
- Step 1: Swab the tops of both the peptide vial and bacteriostatic water vial with alcohol.
- Step 2: Draw your desired amount of BAC water (commonly 1–2 mL) into an insulin syringe.
- Step 3: Inject the water slowly into the peptide vial, aiming at the glass wall — not directly onto the powder.
- Step 4: Swirl the vial gently until fully dissolved — never shake.
- Step 5: Refrigerate at 36–46°F (2–8°C). Use within 4–6 weeks.
Use the dosing calculator to calculate your exact concentration (mcg per unit) and how many units to draw on your syringe.
Frequently Asked Questions
How does Semax work? ▾
Semax is a heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro) that enhances BDNF and NGF expression, stimulates dopaminergic and serotonergic systems, and has melanocortin receptor activity. Despite being derived from ACTH, it does not stimulate adrenal cortex hormone production, making it safe for cognitive research.
What are the key research findings? ▾
- Increases BDNF expression by up to 800% in certain brain regions
- Research shows improved attention, memory consolidation, and learning
- Studied for stroke recovery and neuroprotective applications in Russia
- May enhance immune function through immunomodulatory pathways
What is the typical dosing protocol? ▾
Intranasal administration at 200–600 mcg 1–2 times daily. Beginners start at 200 mcg once daily in the morning. Subcutaneous injection at similar doses is also studied. Cycles commonly run 10–20 days with equal time off between. Often stacked with Selank for combined anxiolytic and cognitive effects.
How should Semax be stored? ▾
Unreconstituted powder should be stored in a freezer or refrigerator away from light and moisture. Once reconstituted with bacteriostatic water, refrigerate at 36–46°F (2–8°C) and use within 4–6 weeks. Never freeze reconstituted peptides.
Need to Calculate Your Semax Dose?
Use our free reconstitution calculator for precise syringe measurements.
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