How do I reconstitute PT-141 (Bremelanotide)?

Add bacteriostatic water slowly to the vial, aiming at the glass wall. Swirl gently until dissolved. Use the TheDoseGuide free dosing calculator to determine your exact concentration and syringe units.

PT-141 (Bremelanotide) — Dosing, Research & Reconstitution Guide

How It Works

PT-141 (bremelanotide) activates melanocortin 4 receptors (MC4R) in the hypothalamus, directly stimulating the neural pathways responsible for sexual desire and arousal. Unlike Viagra/Cialis (which act on blood flow), PT-141 works centrally to increase libido through dopaminergic pathways. It was developed from Melanotan 2 research when sexual arousal was observed as a side effect.

Key Research Findings

FDA-approved (Vyleesi) for hypoactive sexual desire disorder in premenopausal women
Works through central nervous system pathways, not vascular mechanisms
Effective in both males and females for increasing sexual desire
Common side effects include nausea, flushing, and headache

Common Research Protocols

Research Dosing Range

0.5–2 mg administered subcutaneously approximately 45 minutes before desired effect. Not intended for daily use — recommended no more than once every 24 hours and no more than 8 doses per month. Start with a low dose (0.5 mg) to assess tolerance. Nausea is common with the first dose and typically diminishes.

Use our free dosing calculator to determine exact syringe units after reconstitution.

Reconstitution Guide

Follow these steps to properly reconstitute PT-141 (Bremelanotide) for research use:

Step 1: Swab the tops of both the peptide vial and bacteriostatic water vial with alcohol.
Step 2: Draw your desired amount of BAC water (commonly 1–2 mL) into an insulin syringe.
Step 3: Inject the water slowly into the peptide vial, aiming at the glass wall — not directly onto the powder.
Step 4: Swirl the vial gently until fully dissolved — never shake.
Step 5: Refrigerate at 36–46°F (2–8°C). Use within 4–6 weeks.

Use the dosing calculator to calculate your exact concentration (mcg per unit) and how many units to draw on your syringe.

Frequently Asked Questions

How does PT-141 (Bremelanotide) work? ▾

PT-141 (bremelanotide) activates melanocortin 4 receptors (MC4R) in the hypothalamus, directly stimulating the neural pathways responsible for sexual desire and arousal. Unlike Viagra/Cialis (which act on blood flow), PT-141 works centrally to increase libido through dopaminergic pathways. It was developed from Melanotan 2 research when sexual arousal was observed as a side effect.

What are the key research findings? ▾

FDA-approved (Vyleesi) for hypoactive sexual desire disorder in premenopausal women
Works through central nervous system pathways, not vascular mechanisms
Effective in both males and females for increasing sexual desire
Common side effects include nausea, flushing, and headache

What is the typical dosing protocol? ▾

0.5–2 mg administered subcutaneously approximately 45 minutes before desired effect. Not intended for daily use — recommended no more than once every 24 hours and no more than 8 doses per month. Start with a low dose (0.5 mg) to assess tolerance. Nausea is common with the first dose and typically diminishes.

How should PT-141 (Bremelanotide) be stored? ▾

Unreconstituted powder should be stored in a freezer or refrigerator away from light and moisture. Once reconstituted with bacteriostatic water, refrigerate at 36–46°F (2–8°C) and use within 4–6 weeks. Never freeze reconstituted peptides.

PT-141 (Bremelanotide)

How It Works

Key Research Findings

Common Research Protocols

Reconstitution Guide

Frequently Asked Questions

Need to Calculate Your PT-141 (Bremelanotide) Dose?

Related Peptides

Kisspeptin

Melanotan 2