How do I reconstitute Melanotan 2?

Add bacteriostatic water slowly to the vial, aiming at the glass wall. Swirl gently until dissolved. Use the TheDoseGuide free dosing calculator to determine your exact concentration and syringe units.

Melanotan 2 — Dosing, Research & Reconstitution Guide

How It Works

Melanotan 2 is a cyclic heptapeptide that non-selectively activates multiple melanocortin receptors (MC1R through MC5R). MC1R activation produces tanning, MC3R/MC4R activation reduces appetite and increases sexual arousal, and MC5R may affect exocrine function. This broad activity profile makes it multifunctional but also contributes to a wider side effect profile including nausea, flushing, and involuntary arousal.

Key Research Findings

Produces rapid and pronounced skin tanning through eumelanin stimulation
Significant appetite suppression through MC3R/MC4R activation
Led to the development of PT-141 (bremelanotide) for sexual dysfunction
Common side effects include nausea, facial flushing, and darkening of existing moles

Common Research Protocols

Research Dosing Range

Loading phase: 0.25–0.5 mg subcutaneously once daily for 7–14 days. Maintenance: 0.5 mg every 2–3 days. Start with low doses (0.1–0.25 mg) to assess tolerance, as initial nausea is very common. Brief UV exposure enhances tanning effect. Monitor moles for changes during use.

Use our free dosing calculator to determine exact syringe units after reconstitution.

Reconstitution Guide

Follow these steps to properly reconstitute Melanotan 2 for research use:

Step 1: Swab the tops of both the peptide vial and bacteriostatic water vial with alcohol.
Step 2: Draw your desired amount of BAC water (commonly 1–2 mL) into an insulin syringe.
Step 3: Inject the water slowly into the peptide vial, aiming at the glass wall — not directly onto the powder.
Step 4: Swirl the vial gently until fully dissolved — never shake.
Step 5: Refrigerate at 36–46°F (2–8°C). Use within 4–6 weeks.

Use the dosing calculator to calculate your exact concentration (mcg per unit) and how many units to draw on your syringe.

Frequently Asked Questions

How does Melanotan 2 work? ▾

Melanotan 2 is a cyclic heptapeptide that non-selectively activates multiple melanocortin receptors (MC1R through MC5R). MC1R activation produces tanning, MC3R/MC4R activation reduces appetite and increases sexual arousal, and MC5R may affect exocrine function. This broad activity profile makes it multifunctional but also contributes to a wider side effect profile including nausea, flushing, and involuntary arousal.

What are the key research findings? ▾

Produces rapid and pronounced skin tanning through eumelanin stimulation
Significant appetite suppression through MC3R/MC4R activation
Led to the development of PT-141 (bremelanotide) for sexual dysfunction
Common side effects include nausea, facial flushing, and darkening of existing moles

What is the typical dosing protocol? ▾

Loading phase: 0.25–0.5 mg subcutaneously once daily for 7–14 days. Maintenance: 0.5 mg every 2–3 days. Start with low doses (0.1–0.25 mg) to assess tolerance, as initial nausea is very common. Brief UV exposure enhances tanning effect. Monitor moles for changes during use.

How should Melanotan 2 be stored? ▾

Unreconstituted powder should be stored in a freezer or refrigerator away from light and moisture. Once reconstituted with bacteriostatic water, refrigerate at 36–46°F (2–8°C) and use within 4–6 weeks. Never freeze reconstituted peptides.

Melanotan 2

How It Works

Key Research Findings

Common Research Protocols

Reconstitution Guide

Frequently Asked Questions

Need to Calculate Your Melanotan 2 Dose?

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