How do I reconstitute IGF-1 LR3?

Add bacteriostatic water slowly to the vial, aiming at the glass wall. Swirl gently until dissolved. Use the TheDoseGuide free dosing calculator to determine your exact concentration and syringe units.

IGF-1 LR3 — Dosing, Research & Reconstitution Guide

How It Works

IGF-1 LR3 (Long R3 Insulin-like Growth Factor-1) is an 83-amino acid analog of IGF-1 with a 13-amino acid extension at the N-terminus and an arginine substitution at position 3. These modifications give it a dramatically longer half-life (~20-30 hours vs 15 minutes for native IGF-1) and reduce binding to IGF binding proteins, keeping more active IGF-1 in circulation.

Key Research Findings

Promotes muscle hyperplasia — the creation of new muscle cells, not just larger ones
3x more potent than native IGF-1 due to reduced binding protein interaction
Enhances nutrient shuttling, protein synthesis, and nitrogen retention
May improve fat metabolism through direct lipid oxidation effects

Common Research Protocols

Research Dosing Range

20–50 mcg subcutaneously or intramuscularly once daily. Often administered post-workout for maximum effect. Cycles are typically short: 4–6 weeks maximum, followed by equal time off. Some protocols use bilateral intramuscular injection in target muscle groups. This is a powerful compound — careful monitoring is essential.

Use our free dosing calculator to determine exact syringe units after reconstitution.

Reconstitution Guide

Follow these steps to properly reconstitute IGF-1 LR3 for research use:

Step 1: Swab the tops of both the peptide vial and bacteriostatic water vial with alcohol.
Step 2: Draw your desired amount of BAC water (commonly 1–2 mL) into an insulin syringe.
Step 3: Inject the water slowly into the peptide vial, aiming at the glass wall — not directly onto the powder.
Step 4: Swirl the vial gently until fully dissolved — never shake.
Step 5: Refrigerate at 36–46°F (2–8°C). Use within 4–6 weeks.

Use the dosing calculator to calculate your exact concentration (mcg per unit) and how many units to draw on your syringe.

Frequently Asked Questions

How does IGF-1 LR3 work? ▾

IGF-1 LR3 (Long R3 Insulin-like Growth Factor-1) is an 83-amino acid analog of IGF-1 with a 13-amino acid extension at the N-terminus and an arginine substitution at position 3. These modifications give it a dramatically longer half-life (~20-30 hours vs 15 minutes for native IGF-1) and reduce binding to IGF binding proteins, keeping more active IGF-1 in circulation.

What are the key research findings? ▾

Promotes muscle hyperplasia — the creation of new muscle cells, not just larger ones
3x more potent than native IGF-1 due to reduced binding protein interaction
Enhances nutrient shuttling, protein synthesis, and nitrogen retention
May improve fat metabolism through direct lipid oxidation effects

What is the typical dosing protocol? ▾

20–50 mcg subcutaneously or intramuscularly once daily. Often administered post-workout for maximum effect. Cycles are typically short: 4–6 weeks maximum, followed by equal time off. Some protocols use bilateral intramuscular injection in target muscle groups. This is a powerful compound — careful monitoring is essential.

How should IGF-1 LR3 be stored? ▾

Unreconstituted powder should be stored in a freezer or refrigerator away from light and moisture. Once reconstituted with bacteriostatic water, refrigerate at 36–46°F (2–8°C) and use within 4–6 weeks. Never freeze reconstituted peptides.

IGF-1 LR3

How It Works

Key Research Findings

Common Research Protocols

Reconstitution Guide

Frequently Asked Questions

Need to Calculate Your IGF-1 LR3 Dose?

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