How It Works
GHRP-2 (pralmorelin) binds to the growth hormone secretagogue receptor (GHS-R1a) in the pituitary gland and hypothalamus. It stimulates a strong, dose-dependent GH release while also increasing ghrelin, cortisol, and prolactin to a moderate degree. It also inhibits somatostatin, the hormone that suppresses GH release, creating a dual mechanism for GH elevation.
Reconstitution Guide
Follow these steps to properly reconstitute GHRP-2 for research use:
- Step 1: Swab the tops of both the peptide vial and bacteriostatic water vial with alcohol.
- Step 2: Draw your desired amount of BAC water (commonly 1–2 mL) into an insulin syringe.
- Step 3: Inject the water slowly into the peptide vial, aiming at the glass wall — not directly onto the powder.
- Step 4: Swirl the vial gently until fully dissolved — never shake.
- Step 5: Refrigerate at 36–46°F (2–8°C). Use within 4–6 weeks.
Use the dosing calculator to calculate your exact concentration (mcg per unit) and how many units to draw on your syringe.
Frequently Asked Questions
How does GHRP-2 work? ▾
GHRP-2 (pralmorelin) binds to the growth hormone secretagogue receptor (GHS-R1a) in the pituitary gland and hypothalamus. It stimulates a strong, dose-dependent GH release while also increasing ghrelin, cortisol, and prolactin to a moderate degree. It also inhibits somatostatin, the hormone that suppresses GH release, creating a dual mechanism for GH elevation.
What are the key research findings? ▾
- Produces the strongest GH release among the GHRP family of peptides
- Increases IGF-1, lean mass, and recovery markers in research
- Moderate appetite stimulation (less than GHRP-6, more than Ipamorelin)
- May slightly elevate cortisol and prolactin at higher doses
What is the typical dosing protocol? ▾
100–300 mcg subcutaneously 1–3 times daily. Best administered on an empty stomach. Often stacked with CJC-1295 (no DAC) for synergistic GH release. Cycles run 8–12 weeks. Most commonly dosed at 100 mcg to balance GH release with minimal cortisol/prolactin elevation.
How should GHRP-2 be stored? ▾
Unreconstituted powder should be stored in a freezer or refrigerator away from light and moisture. Once reconstituted with bacteriostatic water, refrigerate at 36–46°F (2–8°C) and use within 4–6 weeks. Never freeze reconstituted peptides.