How It Works
Sermorelin mimics natural GHRH and binds to GHRH receptors on the pituitary gland, stimulating the synthesis and secretion of growth hormone. It preserves the hypothalamic-pituitary axis and maintains natural GH pulsatility, making it a preferred option over exogenous GH for age-related GH decline.
Key Research Findings
- Previously FDA-approved for GH deficiency diagnosis and treatment in children
- Shown to increase lean body mass and reduce body fat percentage
- Research supports improved sleep quality and recovery
- Studies suggest enhanced skin elasticity and immune function over time
Common Research Protocols
Research Dosing Range
Typical dosing ranges from 100–300 mcg administered subcutaneously before bedtime (to synergize with natural nocturnal GH pulses). Protocols typically run 3–6 months for optimal results, with periodic blood work to monitor IGF-1 levels.
Use our free dosing calculator to determine exact syringe units after reconstitution.
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Shop Valor Sciences →Reconstitution Guide
Follow these steps to properly reconstitute Sermorelin for research use:
- Step 1: Swab the tops of both the peptide vial and bacteriostatic water vial with alcohol.
- Step 2: Draw your desired amount of BAC water (commonly 1–2 mL) into an insulin syringe.
- Step 3: Inject the water slowly into the peptide vial, aiming at the glass wall — not directly onto the powder.
- Step 4: Swirl the vial gently until fully dissolved — never shake.
- Step 5: Refrigerate at 36–46°F (2–8°C). Use within 4–6 weeks.
Use the dosing calculator to calculate your exact concentration (mcg per unit) and how many units to draw on your syringe.
Frequently Asked Questions
How does Sermorelin work? ▾
Sermorelin mimics natural GHRH and binds to GHRH receptors on the pituitary gland, stimulating the synthesis and secretion of growth hormone. It preserves the hypothalamic-pituitary axis and maintains natural GH pulsatility, making it a preferred option over exogenous GH for age-related GH decline.
What are the key research findings? ▾
- Previously FDA-approved for GH deficiency diagnosis and treatment in children
- Shown to increase lean body mass and reduce body fat percentage
- Research supports improved sleep quality and recovery
- Studies suggest enhanced skin elasticity and immune function over time
What is the typical dosing protocol? ▾
Typical dosing ranges from 100–300 mcg administered subcutaneously before bedtime (to synergize with natural nocturnal GH pulses). Protocols typically run 3–6 months for optimal results, with periodic blood work to monitor IGF-1 levels.
How should Sermorelin be stored? ▾
Unreconstituted powder should be stored in a freezer or refrigerator away from light and moisture. Once reconstituted with bacteriostatic water, refrigerate at 36–46°F (2–8°C) and use within 4–6 weeks. Never freeze reconstituted peptides.
Need to Calculate Your Sermorelin Dose?
Use our free reconstitution calculator for precise syringe measurements.
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